Gene Expression Response of Trichophyton rubrum during Coculture on Keratinocytes Exposed to Antifungal Agents
Identifieur interne : 000060 ( Main/Exploration ); précédent : 000059; suivant : 000061Gene Expression Response of Trichophyton rubrum during Coculture on Keratinocytes Exposed to Antifungal Agents
Auteurs : Tatiana Takahasi Komoto [Brésil] ; Tamires Aparecida Bitencourt [Brésil] ; Gabriel Silva [Brésil] ; Rene Oliveira Beleboni [Brésil] ; Mozart Marins [Brésil] ; Ana Lúcia Fachin [Brésil]Source :
- Evidence-based Complementary and Alternative Medicine : eCAM [ 1741-427X ] ; 2015.
Abstract
Url:
DOI: 10.1155/2015/180535
PubMed: 26257814
PubMed Central: 4516844
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gene Expression Response of <italic>Trichophyton rubrum</italic> during Coculture on Keratinocytes Exposed to Antifungal Agents</title><author><name sortKey="Komoto, Tatiana Takahasi" sort="Komoto, Tatiana Takahasi" uniqKey="Komoto T" first="Tatiana Takahasi" last="Komoto">Tatiana Takahasi Komoto</name><affiliation wicri:level="2"><nlm:aff id="I1">Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Bitencourt, Tamires Aparecida" sort="Bitencourt, Tamires Aparecida" uniqKey="Bitencourt T" first="Tamires Aparecida" last="Bitencourt">Tamires Aparecida Bitencourt</name><affiliation wicri:level="2"><nlm:aff id="I1">Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Silva, Gabriel" sort="Silva, Gabriel" uniqKey="Silva G" first="Gabriel" last="Silva">Gabriel Silva</name><affiliation wicri:level="2"><nlm:aff id="I1">Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Beleboni, Rene Oliveira" sort="Beleboni, Rene Oliveira" uniqKey="Beleboni R" first="Rene Oliveira" last="Beleboni">Rene Oliveira Beleboni</name><affiliation wicri:level="2"><nlm:aff id="I1">Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Marins, Mozart" sort="Marins, Mozart" uniqKey="Marins M" first="Mozart" last="Marins">Mozart Marins</name><affiliation wicri:level="2"><nlm:aff id="I1">Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Fachin, Ana Lucia" sort="Fachin, Ana Lucia" uniqKey="Fachin A" first="Ana Lúcia" last="Fachin">Ana Lúcia Fachin</name><affiliation wicri:level="2"><nlm:aff id="I1">Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26257814</idno><idno type="pmc">4516844</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516844</idno><idno type="RBID">PMC:4516844</idno><idno type="doi">10.1155/2015/180535</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000021</idno><idno type="wicri:Area/Pmc/Curation">000021</idno><idno type="wicri:Area/Pmc/Checkpoint">000045</idno><idno type="wicri:Area/Ncbi/Merge">000821</idno><idno type="wicri:Area/Ncbi/Curation">000821</idno><idno type="wicri:Area/Ncbi/Checkpoint">000821</idno><idno type="wicri:doubleKey">1741-427X:2015:Komoto T:gene:expression:response</idno><idno type="wicri:Area/Main/Merge">000059</idno><idno type="wicri:Area/Main/Curation">000060</idno><idno type="wicri:Area/Main/Exploration">000060</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Gene Expression Response of <italic>Trichophyton rubrum</italic> during Coculture on Keratinocytes Exposed to Antifungal Agents</title><author><name sortKey="Komoto, Tatiana Takahasi" sort="Komoto, Tatiana Takahasi" uniqKey="Komoto T" first="Tatiana Takahasi" last="Komoto">Tatiana Takahasi Komoto</name><affiliation wicri:level="2"><nlm:aff id="I1">Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Bitencourt, Tamires Aparecida" sort="Bitencourt, Tamires Aparecida" uniqKey="Bitencourt T" first="Tamires Aparecida" last="Bitencourt">Tamires Aparecida Bitencourt</name><affiliation wicri:level="2"><nlm:aff id="I1">Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Silva, Gabriel" sort="Silva, Gabriel" uniqKey="Silva G" first="Gabriel" last="Silva">Gabriel Silva</name><affiliation wicri:level="2"><nlm:aff id="I1">Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Beleboni, Rene Oliveira" sort="Beleboni, Rene Oliveira" uniqKey="Beleboni R" first="Rene Oliveira" last="Beleboni">Rene Oliveira Beleboni</name><affiliation wicri:level="2"><nlm:aff id="I1">Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Marins, Mozart" sort="Marins, Mozart" uniqKey="Marins M" first="Mozart" last="Marins">Mozart Marins</name><affiliation wicri:level="2"><nlm:aff id="I1">Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Fachin, Ana Lucia" sort="Fachin, Ana Lucia" uniqKey="Fachin A" first="Ana Lúcia" last="Fachin">Ana Lúcia Fachin</name><affiliation wicri:level="2"><nlm:aff id="I1">Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Unidade de Biotecnologia, Universidade de Ribeirão Preto, Avenida Costábile Romano 2201, 14096-900 Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author></analytic><series><title level="j">Evidence-based Complementary and Alternative Medicine : eCAM</title><idno type="ISSN">1741-427X</idno><idno type="e-ISSN">1741-4288</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Trichophyton rubrum</italic> is the most common causative agent of dermatomycoses worldwide, causing infection in the stratum corneum, nails, and hair. Despite the high prevalence of these infections, little is known about the molecular mechanisms involved in the fungal-host interaction, particularly during antifungal treatment. The aim of this work was to evaluate the gene expression of <italic>T. rubrum</italic> cocultured with keratinocytes and treated with the flavonoid <italic>trans</italic>-chalcone and the glycoalkaloid <italic>α</italic>-solanine. Both substances showed a marked antifungal activity against <italic>T. rubrum</italic> strain CBS (MIC = 1.15 and 17.8 <italic>µ</italic>g/mL, resp.). Cytotoxicity assay against HaCaT cells produced IC<sub>50</sub> values of 44.18 to <italic>trans</italic>-chalcone and 61.60 <italic>µ</italic>M to <italic>α</italic>-solanine. The interaction of keratinocytes with <italic>T. rubrum</italic> conidia upregulated the expression of genes involved in the glyoxylate cycle, ergosterol synthesis, and genes encoding proteases but downregulated the ABC transporter <italic>Tru</italic>MDR2 gene. However, both antifungals downregulated the ERG1 and ERG11, metalloprotease 4, serine proteinase, and <italic>Tru</italic>MDR2 genes. Furthermore, the <italic>trans</italic>-chalcone downregulated the genes involved in the glyoxylate pathway, isocitrate lyase, and citrate synthase. Considering the urgent need for more efficient and safer antifungals, these results contribute to a better understanding of fungal-host interactions and to the discovery of new antifungal targets.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gupta, A K" uniqKey="Gupta A">A. K. Gupta</name></author><author><name sortKey="Nakrieko, K A" uniqKey="Nakrieko K">K.-A. 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Paião</name></author><author><name sortKey="Fachin, A L" uniqKey="Fachin A">A. L. Fachin</name></author><author><name sortKey="Martinez Rossi, N M" uniqKey="Martinez Rossi N">N. M. Martinez-Rossi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author><author><name sortKey="Yu, L" uniqKey="Yu L">L. Yu</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J. Yang</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Peng, J" uniqKey="Peng J">J. Peng</name></author><author><name sortKey="Jin, Q" uniqKey="Jin Q">Q. Jin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region></list><tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Komoto, Tatiana Takahasi" sort="Komoto, Tatiana Takahasi" uniqKey="Komoto T" first="Tatiana Takahasi" last="Komoto">Tatiana Takahasi Komoto</name></region><name sortKey="Beleboni, Rene Oliveira" sort="Beleboni, Rene Oliveira" uniqKey="Beleboni R" first="Rene Oliveira" last="Beleboni">Rene Oliveira Beleboni</name><name sortKey="Bitencourt, Tamires Aparecida" sort="Bitencourt, Tamires Aparecida" uniqKey="Bitencourt T" first="Tamires Aparecida" last="Bitencourt">Tamires Aparecida Bitencourt</name><name sortKey="Fachin, Ana Lucia" sort="Fachin, Ana Lucia" uniqKey="Fachin A" first="Ana Lúcia" last="Fachin">Ana Lúcia Fachin</name><name sortKey="Marins, Mozart" sort="Marins, Mozart" uniqKey="Marins M" first="Mozart" last="Marins">Mozart Marins</name><name sortKey="Silva, Gabriel" sort="Silva, Gabriel" uniqKey="Silva G" first="Gabriel" last="Silva">Gabriel Silva</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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